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Remark: Barbiturates may perhaps increase adverse effects, including respiratory melancholy, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates maximize metabolism and decrease blood concentrations of TCAs.pentobarbital will reduce the extent or result of diltiazem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will lessen the extent or result of clarithromycin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unidentified.
pentobarbital will lessen the extent or outcome of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Pitolisant exposure is lessened by fifty% if coadministered with solid CYP3A4 inducers.
pentobarbital will reduce the level or impact of levoketoconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Not known.
pentobarbital will minimize the extent or result of triamcinolone acetonide injectable suspension by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
With therapeutic doses of TCAs, barbiturates improve metabolism and decrease blood concentrations of TCAs.
pentobarbital will lower the level or impact of methylprednisolone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will lower the read more level or effect of stiripentol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. If struggling to stay clear of coadministration of stiripentol with solid CYP3A4 inducers, enhance stiripentol dose.
With therapeutic doses of TCAs, barbiturates enhance metabolism and decrease blood concentrations of TCAs.
pentobarbital will reduce the extent or outcome of atazanavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Not known.
pentobarbital will reduce the extent or impact of loratadine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
With therapeutic doses of TCAs, barbiturates enhance metabolism and reduce blood concentrations of TCAs.
pentobarbital will reduce the level or influence of fostemsavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.